MyBioSource.com's RABBIT ANTI MUNC-18 (pSer515) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The RABBIT ANTI MUNC-18 (pSer515) Antibody was generated using Munc18-1, and STXBP1 as the antigen and it reacts with Human, Mouse, Bovine, Canine, Chicken/Bird, Non-Human Primate, and Xenopus/Amphibian.
Description
MBS221521 recognises Munc-18 phosphorylated at serine 515, a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release